Type 1 diabetes usually develops due to an autoimmune disorder. This is when the body's immune system behaves inappropriately and starts seeing one of its own tissues as foreign.
In the case of type 1 diabetes, the islet cells of the pancreas that produce insulin are seen as the "enemy" by mistake. The body then creates antibodies to fight the "foreign" tissue and destroys the islet cells' ability to produce insulin.
The lack of sufficient insulin thereby results in diabetes. It is unknown why this autoimmune diabetes develops. Most often it is a genetic tendency. Sometimes it follows a viral infection such as mumps, rubella, cytomegalovirus, measles, influenza, encephalitis, polio, or Epstein-Barr virus.
Certain people are more genetically prone to this happening although why this occurs is not know. Thus, 2 people may be infected with the same virus and only one of them who is genetically prone will go on to develop diabetes.
Other less common (very rare) causes of type 1 diabetes include injury to the pancreas from toxins, trauma, or after the surgical removal of the majority (or all) of the pancreas.
Hereditary Tendencies in Type 1 Diabetes
Type 1 diabetes tends to have less tendency to have other family members affected with diabetes than type 2 diabetes. In the first large family study of diabetes, less than 4% of parents and 6% of siblings of a person with diabetes also had diabetes.
In studies with identical twins, less than 50% of the siblings of a person with diabetes also had diabetes versus almost 100% of siblings of people with type 2 diabetes. Children of fathers with type 1 diabetes are more likely to develop type 1 diabetes than children of mothers with type 1 diabetes.
Type 1 Diabetes Treatments
Type 1 diabetes must be treated with insulin. This involves injecting insulin under the skin—in the fat—for it to get absorbed into the bloodstream where it can then access all the cells of the body that require it. Insulin cannot be taken as a pill because the juices in the stomach would destroy the insulin before it could work. Remember, insulin is a hormone, and like all other hormones, insulin is a protein and therefore it has a very important 3-dimensional structure which is destroyed by the acid in the stomach. Even if it did make it through the stomach, the digestive enzymes secreted by the digestive part of the pancreas would digest the insulin protein molecule. Scientists are looking for new ways to give insulin. But today, shots are the most widely used method. Some new insulin pumps are being developed and tested.
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